Health Canada approves Pfizer's COVID-19 therapeutic
You would think that the hesitant ones and the antis would be all over this one like a fat kid on a Smartie.
After all it is pretty much exactly what they have been demanding...
Not from what I am seeing.
First the anti's scream
It is simply rebranded Ivermectin. Nope:
How Does Pfizer's Paxlovid Compare With Ivermectin?"A new rumor claims that Paxlovid, Pfizer's Covid drug, is merely a "dressed up" ivermectin molecule with little difference other than price. The term "Pfizermectin" is even being used to emphasize this. But biochemical and pharmacokinetic data say otherwise. Here are the numbers.
Bottom line:
It is abundantly clear that the "Pfizermectin" myth is just that. PF-07321332 is a potent enzymatic inhibitor of Mpro with proven efficacy in clinical trials. Ivermectin has very poor potency in this same assay. Ivermectin, if it works at all, is certainly not functioning as a protease inhibitor.
Based on in vitro studies, Ivermectin is a weak inhibitor of viral replication in cultured cells.
But the antiviral inhibition of ivermectin is weak enough that even at high or multiple doses of the drug blood concentrations do not reach its cellular assay IC50 of 2µM.
PF-07321332 is a potent inhibitor in both the enzymatic and call-based assays.
The drug reaches and remains at blood concentrations sufficient to inhibit 90% of viral replication in cells for one day and does so well below toxic levels.
These data tell us that ivermectin neither inhibits the viral protease in an enzyme-based assay nor slows the production of virus in cells while Pfizer's drug does both. If ivermectin is proven to be an effective Covid treatment it must be acting by some yet-unknown mechanism."
https://www.acsh.org/news/2021/12/02/how-does-pfizers-paxlovid-compare-ivermectin-15967And:
Fact Check-Pfizer's trial COVID-19 drug is not the same as ivermectinhttps://www.reuters.com/article/factcheck-coronavirus-pfizer-idUSL1N2R11T5Next of course it
There have been NO Clinical Trials! Wrong again:
"After months of clinical trials, Pfizer reported in November that Paxlovid reduced the risk of hospitalization or death by an impressive 89 per cent compared to a placebo in non-hospitalized high-risk adults with COVID-19."So the fallback:
It's too new. Don't trust it. My Body My Choice.Whatever. You can lead a horse to water, but you cannot make him drink. Regardless of how long you hold his head under.
Nog